Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.

  title={Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.},
  author={Gemma G Kenter and Marij J. P. Welters and A. Rob P. M. Valentijn and Margriet J G Lowik and Dorien M. A. Berends-van der Meer and Annelies P G Vloon and Farah Essahsah and Lorraine M. Fathers and Rienk Offringa and Jan Wouter Drijfhout and Amon R. Wafelman and Jaap Oostendorp and Gert Jan J Fleuren and Sjoerd H van der Burg and Cornelis J M Melief},
  journal={The New England journal of medicine},
  volume={361 19},
BACKGROUND Vulvar intraepithelial neoplasia is a chronic disorder caused by high-risk types of human papillomavirus (HPV), most commonly HPV type 16 (HPV-16). Spontaneous regression occurs in less than 1.5% of patients, and the rate of recurrence after treatment is high. METHODS We investigated the immunogenicity and efficacy of a synthetic long-peptide vaccine in women with HPV-16-positive, high-grade vulvar intraepithelial neoplasia. Twenty women with HPV-16-positive, grade 3 vulvar… CONTINUE READING
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Immuno - 34 . therapy of established ( pre ) malignant disease by synthetic long peptide vaccines

  • CJ Melief, SH vanderBurg
  • Nat Rev Cancer
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Induction of tumor - specific CD 4 + and CD 8 + T - cell immunity in cervical cancer patients by an HPV 16 E 6 and E 7 long - peptide vaccine

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