Vaccenic Acid Feeding Increases Tissue Levels of Conjugated Linoleic Acid and Suppresses Development of Premalignant Lesions in Rat Mammary Gland

@article{Banni2001VaccenicAF,
  title={Vaccenic Acid Feeding Increases Tissue Levels of Conjugated Linoleic Acid and Suppresses Development of Premalignant Lesions in Rat Mammary Gland},
  author={S. Banni and E. Angioni and E. Murru and G. Carta and M. Paola Melis and D. Bauman and Y. Dong and C. Ip},
  journal={Nutrition and Cancer},
  year={2001},
  volume={41},
  pages={91 - 97}
}
  • S. Banni, E. Angioni, +5 authors C. Ip
  • Published 2001
  • Medicine, Biology
  • Nutrition and Cancer
  • The objective of this report was to determine whether vaccenic acid (t11-18:1) is converted efficiently to conjugated linoleic acid (c9,t11-18:2, CLA) in rats via the Δ2-desaturase reaction and, if so, whether vaccenic acid could substitute for CLA as an anticancer agent. In Study 1, rats were fed 1%, 2%, or 3% vaccenic acid in their diet, and tissue levels of CLA and CLA metabolites were determined in liver and mammary gland. In general, concentrations of CLA and CLA metabolites increased… CONTINUE READING
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