Vaccenic Acid Feeding Increases Tissue Levels of Conjugated Linoleic Acid and Suppresses Development of Premalignant Lesions in Rat Mammary Gland

@article{Banni2001VaccenicAF,
  title={Vaccenic Acid Feeding Increases Tissue Levels of Conjugated Linoleic Acid and Suppresses Development of Premalignant Lesions in Rat Mammary Gland},
  author={Sebastiano Banni and Elisabetta Angioni and Elisabetta Murru and Gianfranca Carta and M Paola Melis and Dale Elton Bauman and Yan Dong and Clement Ip},
  journal={Nutrition and Cancer},
  year={2001},
  volume={41},
  pages={91 - 97}
}
The objective of this report was to determine whether vaccenic acid (t11-18:1) is converted efficiently to conjugated linoleic acid (c9,t11-18:2, CLA) in rats via the Δ2-desaturase reaction and, if so, whether vaccenic acid could substitute for CLA as an anticancer agent. In Study 1, rats were fed 1%, 2%, or 3% vaccenic acid in their diet, and tissue levels of CLA and CLA metabolites were determined in liver and mammary gland. In general, concentrations of CLA and CLA metabolites increased… 

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Vaccenic acid metabolism in the liver of rat and bovine

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The data suggest that early pathological lesions may be particularly sensitive to CLA, and the research on CLA-responsive biomarkers also has a practical side because these assays can be applied to biopsied human tissue samples in future CLA intervention trials.