Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats

@article{Zhu2018VaccarinAA,
  title={Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats},
  author={Xuexue Zhu and Zhou Zhou and Qingfeng Zhang and Weiwei Cai and Yue-tao Zhou and Haijian Sun and Liying Qiu},
  journal={Journal of Cellular Biochemistry},
  year={2018},
  volume={119},
  pages={926 - 937}
}
Sympathetic overdrive, activation of renin angiotensin systems (RAS), and oxidative stress are vitally involved in the pathogenesis of hypertension and cardiovascular remodeling. We recently identified that vaccarin protected endothelial cell function from oxidative stress or high glucose. In this study, we aimed to investigate whether vaccarin attenuated hypertension and cardiovascular remodeling. Two‐kidney one‐clip (2K1C) model rats were used, and low dose of vaccarin (10 mg/kg), high dose… 
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