Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats

  title={Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats},
  author={Xuexue Zhu and Zhou Zhou and Qingfeng Zhang and Weiwei Cai and Yue-tao Zhou and Haijian Sun and Liying Qiu},
  journal={Journal of Cellular Biochemistry},
  pages={926 - 937}
Sympathetic overdrive, activation of renin angiotensin systems (RAS), and oxidative stress are vitally involved in the pathogenesis of hypertension and cardiovascular remodeling. We recently identified that vaccarin protected endothelial cell function from oxidative stress or high glucose. In this study, we aimed to investigate whether vaccarin attenuated hypertension and cardiovascular remodeling. Two‐kidney one‐clip (2K1C) model rats were used, and low dose of vaccarin (10 mg/kg), high dose… 
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats
The findings suggest that the protective effects of vaccarin on the right kidney in renovascular hypertension are possibly due to downregulation of fibrosis, inflammatory molecules, oxidative stress, Ang II, and AT1 receptor levels.
Sodium Thiosulfate Ameliorates Renovascular Hypertension-Induced Renal Dysfunction and Injury in Rats
The results suggest that STS treatment could ameliorate RVHT hypertension and renal oxidative injury through antioxidant, antifibrotic, and antiapoptotic mechanisms.
Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats
Naringenin attenuated renal damage in a rat model of renovascular hypertension by normalizing the imbalance of renin-angiotensin system activation, suggesting a potential treatment strategy for hypertensive nephropathy.
Protective Effects and Mechanisms of Vaccarin on Vascular Endothelial Dysfunction in Diabetic Angiopathy
It is found that VAC attenuated increased blood glucose, increased glucose and insulin tolerance, relieved the disorder of lipid metabolism and oxidative stress, and improved endothelium-dependent vasorelaxation in STZ/HFD-induced T2DM mice.
Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?
The present review attempts to focus on the current findings and molecular mechanisms of curcumin in the treatment of hypertensive vascular remodeling, as well as some favorable pharmacokinetics or pharmacodynamics profiles in arterial hypertension.
Antihypertensive Effects of Gynura divaricata (L.) DC in Rats with Renovascular Hypertension
Findings indicate that GD shows beneficial effects against high blood pressure by modulating the RAAS in the cardio-renal syndrome, and should be considered an effective traditional medicine in hypertension treatment.
Salusin-α mitigates diabetic nephropathy via inhibition of the Akt/mTORC1/p70S6K signaling pathway in diabetic rats
It is demonstrated that salusin-α exerted protective effect against diabetic nephropathy via reduced oxidative stress and fibrosis, dependent on inactivation of the Akt/mTORC1/p70S6K signaling cascade.
Mechanism of herbal medicine on hypertensive nephropathy ( Review )
Progress on the basic research on the treatment of hypertensive nephropathy with herbal medicine is reviewed, including regulation of the renin angiotensin system, inhibition of sympathetic excitation, antioxidant stress and anti‐inflam‐ matory protection of endothelial cells, and improvement of obesity‐associated factors.


Silencing salusin-β attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats
Results indicate that silencing salusin-β attenuates hypertension and cardiovascular remodeling in spontaneously hypertensive rats (SHR).
Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus
The beneficial effects of ExT on renovascular hypertension may be, in part, through the RAS-ROS-glutamate pathway in the paraventricular nucleus (PVN).
Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats.
RSD attenuated hypertension, improved vascular remodeling, and reduced vascular fibrosis through decreased sympathetic activity in the 2K1C rat model, but it did not change the kidney size, renal apoptosis, or renal caspase-3 expression, which could suggest possible clinical efficacy of RSD for renovascular hypertension.
AT1 receptors prevent salt-induced vascular dysfunction in isolated middle cerebral arteries of 2 kidney-1 clip hypertensive rats.
The results suggest that the sustained effects of elevated ANG II levels in 2K1C hypertension maintain endothelium-dependent vasodilatation via AT1 receptor-mediated preservation of antioxidant defense mechanisms despite significant elevations in blood pressure and salt-induced suppression of PRA.
Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats
Chymase might play an important role in vascular dysfunction via augmentation both of matrix metalloproteinase-9 activity and monocyte/macrophage accumulation in SHR-SP, and its inhibition may be useful for preventing vascular remodeling and prolonging survival.
Angiotensin-(1–9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Angiotensin-(1–9) reduces hypertension, ameliorates structural alterations (hypertrophy and fibrosis), oxidative stress in the heart and aorta and improves cardiac and endothelial function in hypertensive rats.
Salusin-β in paraventricular nucleus increases blood pressure and sympathetic outflow via vasopressin in hypertensive rats.
Salusin-β in the PVN increases blood pressure, heart rate, and sympathetic outflow via both circulating AVP and AVP in the RVLM in hypertensive rats.
Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension
H2S prevents activation of BMP4/COX-2 pathway in hypertension, which may be involved in the ameliorative effect of H2S on endothelial impairment, and provides new target for prevention and therapy of hypertension.
Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment.
  • E. Schiffrin
  • Medicine, Biology
    American journal of hypertension
  • 2004
Effect of acute administration of vitamin C on muscle sympathetic activity, cardiac sympathovagal balance, and baroreflex sensitivity in hypertensive patients.
Results indicate that acute administration of vitamin C is able to reduce cardiovascular adrenergic drive in hypertensive patients, which suggests that oxidative stress is involved in the regulation of sympathetic activity in essential hypertension.