VX-222, a non-nucleoside NS5B polymerase inhibitor, in telaprevir-based regimens for genotype 1 hepatitis C virus infection.

@article{Bisceglie2014VX222AN,
  title={VX-222, a non-nucleoside NS5B polymerase inhibitor, in telaprevir-based regimens for genotype 1 hepatitis C virus infection.},
  author={Adrian M Di Bisceglie and Mark S Sulkowski and Ed Gane and I M for the New Paradigm of HCV Therapy Meeting Part Jacobson and David N. Nelson and Cynthia DeSouza and K{\'a}tia Cristiane Alves and Shelley J George and Tara L. Kieffer and Eileen Z. Zhang and Robert Kauffman and Mohammed Asmal and Margaret James Koziel},
  journal={European journal of gastroenterology & hepatology},
  year={2014},
  volume={26 7},
  pages={761-73}
}
OBJECTIVE To investigate in this phase 2a study (ZENITH) the safety, tolerability, and antiviral activity of VX-222, a selective, non-nucleoside inhibitor of hepatitis C virus (HCV) NS5B polymerase, combined with various telaprevir-based regimens for treatment of genotype 1 HCV. METHODS In total, 152 treatment-naive patients received VX-222+telaprevir ('DUAL' regimen; n=47), with ribavirin ('TRIPLE' regimen; n=46), or with peginterferon+ribavirin ('QUAD' regimen; n=59) for 12 weeks. Patients… CONTINUE READING
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