VUR is a risk factor for urinary tract infections (UTIs) and reflux nephropathy (RN), a specific renal lesion characterized by chronic tubulointerstitial inflammation, fibrosis and destruction


934 INTRODUCTION Primary vesicoureteric reflux (VUR) is a congenital defect of the ureterovesical junction (UVJ), affecting up to 1% of children (Burger and Smith, 1971; Chapman et al., 1985; Sargent, 2000). The UVJ consists of the intravesical ureter, which is the portion of the ureter that inserts through the bladder wall, and the trigone, or bladder… (More)