VSV oncolytic virotherapy in the B16 model depends upon intact MyD88 signaling.

Abstract

We show here, for the first time to our knowledge, that the antitumor therapy of oncolytic vesicular stomatitis virus (VSV) in the B16ova model depends upon signaling through myeloid differentiation primary response gene 88 (MyD88) in host cells. VSV-mediated therapy of B16ova tumors was abolished in MyD88(-/-) mice despite generation of antigen-specific T… (More)
DOI: 10.1038/mt.2010.225

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@article{Wongthida2011VSVOV, title={VSV oncolytic virotherapy in the B16 model depends upon intact MyD88 signaling.}, author={Phonphimon Wongthida and R. Diaz and Feorillo Galivo and Timothy J. Kottke and Jill Thompson and Alan A Melcher and Richard G. Vile}, journal={Molecular therapy : the journal of the American Society of Gene Therapy}, year={2011}, volume={19 1}, pages={150-8} }