VRACs and other ion channels and transporters in the regulation of cell volume and beyond

Abstract

Cells need to regulate their volume to counteract osmotic swelling or shrinkage, as well as during cell division, growth, migration and cell death. Mammalian cells adjust their volume by transporting potassium, sodium, chloride and small organic osmolytes using plasma membrane channels and transporters. This generates osmotic gradients, which drive water in… (More)
DOI: 10.1038/nrm.2016.29

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