VPS10P-domain receptors — regulators of neuronal viability and function

  title={VPS10P-domain receptors — regulators of neuronal viability and function},
  author={Thomas E. Willnow and Claus Munck Petersen and Anders Nykjaer},
  journal={Nature Reviews Neuroscience},
VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class of type-1 receptors that are expressed in neurons. Family members are multifunctional proteins that target a range of ligands, including trophic factors and neuropeptides but also other transmembrane proteins. New findings have revealed unexpected roles for VPS10P-domain receptors as regulators of neuronal viability and function through the regulation of both protein transport and signal transduction… CONTINUE READING


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Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

  • Petersen, M C.
  • J. Biol
  • 1997
Highly Influential
7 Excerpts

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

  • Baum, E A.
  • Mol. Psychiatry
  • 2008

CNS neurons store and secrete BDNF, not pro-BDNF

  • Matsumoto, T. et al. Biosynthesis, processing of endogenous BDNF
  • Nature Neurosci. 11, 131–133
  • 2008

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

  • R Al-Shawi
  • Eur. J. Neurosci
  • 2008

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