VPS10P-domain receptors — regulators of neuronal viability and function

@article{Willnow2008VPS10PdomainR,
  title={VPS10P-domain receptors — regulators of neuronal viability and function},
  author={Thomas E. Willnow and Claus Munck Petersen and Anders Nykjaer},
  journal={Nature Reviews Neuroscience},
  year={2008},
  volume={9},
  pages={899-909}
}
VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class of type-1 receptors that are expressed in neurons. Family members are multifunctional proteins that target a range of ligands, including trophic factors and neuropeptides but also other transmembrane proteins. New findings have revealed unexpected roles for VPS10P-domain receptors as regulators of neuronal viability and function through the regulation of both protein transport and signal transduction… CONTINUE READING

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