VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse.

@article{Rosnet1999VPREB3CC,
  title={VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse.},
  author={Olivier Rosnet and M. G. Matt{\'e}i and Oliver Delattre and Celine Schiff},
  journal={Cytogenetics and cell genetics},
  year={1999},
  volume={87 3-4},
  pages={
          205-8
        }
}
The pre-B cell receptor (pre-BCR) regulates pre-B cell expansion and allelic exclusion at the immunoglobulin (Ig) heavy chain locus and mediates the selection of Ig heavy chain variable gene segments. During the early phase of pre-BCR assembly in the mouse, the membrane Ig mu heavy chain transiently associates with the VPREB3 protein in the endoplasmic reticulum. Here, we present the human VPREB3 cDNA sequence and its B cell-specific expression in hematopoietic cell lines. We have localized… CONTINUE READING