VPA-induced apoptosis and behavioral deficits in neonatal mice.

  title={VPA-induced apoptosis and behavioral deficits in neonatal mice.},
  author={Carrie L. Yochum and Peter J. Dowling and Kenneth R. Reuhl and George W. Wagner and X. T. Ming},
  journal={Brain research},
Sodium valproate (VPA) administered to neonatal mice causes cognitive and motor deficits similar to those observed in humans with autism. In an effort to further evaluate similarities between early VPA exposure and autism, the present study examined treated mice for deficits in social behavior and neuronal damage. BALB/c mice injected on P14 with 400 mg/kg VPA engaged in fewer social interactions (including ano-genital sniffs, allogrooming, and crawl-under/over behaviors) than control mice… CONTINUE READING

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