VPA-induced apoptosis and behavioral deficits in neonatal mice

@article{Yochum2008VPAinducedAA,
  title={VPA-induced apoptosis and behavioral deficits in neonatal mice},
  author={Carrie L. Yochum and P. Dowling and K. Reuhl and G. Wagner and X. Ming},
  journal={Brain Research},
  year={2008},
  volume={1203},
  pages={126-132}
}
  • Carrie L. Yochum, P. Dowling, +2 authors X. Ming
  • Published 2008
  • Psychology, Medicine
  • Brain Research
  • Sodium valproate (VPA) administered to neonatal mice causes cognitive and motor deficits similar to those observed in humans with autism. In an effort to further evaluate similarities between early VPA exposure and autism, the present study examined treated mice for deficits in social behavior and neuronal damage. BALB/c mice injected on P14 with 400 mg/kg VPA engaged in fewer social interactions (including ano-genital sniffs, allogrooming, and crawl-under/over behaviors) than control mice… CONTINUE READING
    83 Citations

    Figures and Topics from this paper.

    Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid
    • 15
    Valproic Acid Exposure during Early Postnatal Gliogenesis Leads to Autistic-like Behaviors in Rats
    • 6
    • PDF
    Aberrant Development and Synaptic Transmission of Cerebellar Cortex in a VPA Induced Mouse Autism Model
    • 8
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 31 REFERENCES
    Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism
    • 569
    • PDF
    A New Neurobehavioral Model of Autism in Mice: Pre- and Postnatal Exposure to Sodium Valproate
    • 191
    Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism.
    • 306
    Linking etiologies in humans and animal models: studies of autism.
    • 211
    Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
    • 2,225
    • PDF
    Purkinje Cell Size Is Reduced in Cerebellum of Patients with Autism
    • 273
    Neuroanatomic observations of the brain in autism: a review and future directions
    • 797