VPA Inhibits P19 Neural Differentiation through Redox Dysregulation and Oxidative Stress

@inproceedings{Jacob2017VPAIP,
  title={VPA Inhibits P19 Neural Differentiation through Redox Dysregulation and Oxidative Stress},
  author={Benjamin Richard Jacob and Ted B. Piorczynski and Jason M. Hansen},
  year={2017}
}
Valproic acid (VPA), a common anti-epileptic drug and migraine reducer, causes deficiencies in developing nervous systems and can be manifested as neural tube defects (NTDs). The appearance of these defects is believed to be due to the disruption of the redox state of differentiating cells. P19 cells are embryo carcinoma cells and are an established model for neurogenesis. Preliminary work in P19 cells shows that during neural differentiation, the glutathione (GSH) redox potential (Eh) shifts… CONTINUE READING