VP1 protein of Foot-and-mouth disease virus (FMDV) impairs baculovirus surface display.

@article{Peralta2013VP1PO,
  title={VP1 protein of Foot-and-mouth disease virus (FMDV) impairs baculovirus surface display.},
  author={Andrea V Peralta and Guillermo Andr{\'e}s Maroniche and Victoria Alfonso and Paula Molinari and Oscar Taboga},
  journal={Virus research},
  year={2013},
  volume={175 1},
  pages={
          87-90
        }
}
The Foot-and-mouth disease virus (FMDV) causes important economical losses in livestock farming. In order to develop a novel subunit vaccine against FMDV, we constructed recombinant baculoviruses that display the protein VP1 of FMDV on their surface, with either polar (fused to gp64) or nonpolar (fused to anchor membrane from VSV-G protein) distribution. Insect cells infected with the different recombinant baculoviruses expressed VP1 fusion protein to high levels. However, the recombinant VP1… CONTINUE READING

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