VNS induced desynchronization in gamma bands correlates with positive clinical outcome in temporal lobe pharmacoresistant epilepsy

@article{Fraschini2013VNSID,
  title={VNS induced desynchronization in gamma bands correlates with positive clinical outcome in temporal lobe pharmacoresistant epilepsy},
  author={Matteo Fraschini and Monica Puligheddu and Matteo Demuru and Lorenzo Polizzi and Alberto Maleci and Giorgio Tamburini and Socrate Congia and Marco Bortolato and Francesco Marrosu},
  journal={Neuroscience Letters},
  year={2013},
  volume={536},
  pages={14-18}
}

The Effectiveness of Vagus Nerve Stimulation in Drug-Resistant Epilepsy Correlates with Vagus Nerve Stimulation-Induced Electroencephalography Desynchronization

This study is the first to statistically correlate interictal cortical desynchronization during ON periods with reduction in seizure frequency, and supports the hypothesis that the antiseizure effect of VNS is mediated by cortical des synchronization.

EEG Reactivity Predicts Individual Efficacy of Vagal Nerve Stimulation in Intractable Epileptics

A new statistical model with which EEG reactivity to external stimuli during routine presurgical evaluation can be seen as a promising avenue for the identification of patients with favorable VNS outcome is presented.

The Immediate Effects of Vagus Nerve Stimulation in Intractable Epilepsy: An Intra-operative Electrocorticographic Analysis

This study showed the reduction of epileptogenic spikes and spread areas of the spikes by VNS as immediate effects, electrophysiologically.

Prediction of the Responsiveness to Vagus-Nerve Stimulation in Patients with Drug-Resistant Epilepsy via Directed-Transfer-Function Analysis of Their Perioperative Scalp EEGs

It is demonstrated that the presurgical DTF profiles of responders were different from those of nonresponders, and a presurgical normal DTF profile may predict good responsiveness to VNS.

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Vagus nerve stimulation induces progressive EEG changes in the form of clustering of epileptiform activity followed by progressively increased periods of spike-free intervals, which may reflect the mechanism of action of VNS in achieving seizure control: alternating synchronization and desynchronization of EEG, with the latter being progressively the dominant feature.

Chronic Vagus Nerve Stimulation Increases the Latency of the Thalamocortical Somatosensory Evoked Potential

The findings suggest that chronic vagus nerve stimulation does alter neuronal networks outside of the brain stem vagus system, and may potentially provide a means to clinically monitor and titrate this therapy.

Vagus Nerve Stimulation Has No Effect on Awake EEG Rhythms in Humans

It is concluded that VNS at the parameters in current clinical use does not alter awake EEG background rhythms, and the mechanism mediating acute antiepileptic effect remains unknown.

Vagus nerve stimulation for epilepsy: a review

No indication other than refractory partial seizures in adults has been the subject of controlled trials, but post-marketing experience and uncontrolled reports indicate comparable efficacy and safety in a wide range of epilepsies, partial and generalized, idiopathic, cryptogenic, or symptomatic, in patients of all ages.

Electrophysiologic Studies of Cervical Vagus Nerve Stimulation in Humans: II. Evoked Potentials

Evidence from studies of experimental animals indicates that electrical stimulation of the vagus nerve not only can alter the EEG but evokes activity in specific brain areas, as part of a clinical trial of chronic vagal stimulation for control of epilepsy.

Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy

Increased thalamic synaptic activities probably mediate some antiseizure effects of VNS, and future studies should examine neurotransmitter-receptor alterations in reticular and specific thalamus and cerebellum nuclei during VNS.