VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis.

@article{Muraro2000VLA4CD49dDO,
  title={VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis.},
  author={Paolo Antonio Muraro and Thomas P. Leist and Bibiana Bielekova and Henry F. McFarland},
  journal={Journal of neuroimmunology},
  year={2000},
  volume={111 1-2},
  pages={186-94}
}
Effects on adhesion molecules of immune cells might contribute to the mode of action of interferon-beta (IFN-beta) in multiple sclerosis (MS). We have serially monitored the cell surface expression of integrins CD49d (VLA-4) and CD11a (LFA-1) on fresh T lymphocyte subpopulations from 5 MS patients monthly for 2 months prior to treatment and for 3 months on… CONTINUE READING