Corpus ID: 86281840


  author={Slavica Stojnev},
In addition to the classical role in the homeostasis of calcium and phosphorus, vitamin D shows a regulatory effect on a number of different cells, especially its anti-proliferative and pro-differential biological function. Through its own receptor in the immune cells, vitamin D increases the phagocytic activity of macrophages and NK cells. Also, by binding to the regulatory sequences of antimicrobial peptides genes, vitamin D increases the microbicidal activity of phagocytes. Inhibition of… Expand

Figures from this paper

Immunology and Its Relation with Food Components: An Overview
Immunology involves all the defence mechanisms occurring in the body after the invasion of any infectious agent and the ability to resist this infection is referred to as immunity. The early andExpand
Immunomodulatory potential of nanocurcumin-based formulation
The promising results of this study indicated the significant immunomodulatory effect of nanocurcumin-based formulation compared to the curcumin, which could be used against various inflammatory disorders such as allergy, asthma, autoimmune diseases, coeliac disease, inflammatory bowel disease, etc. Expand
Association of Vitamın D Deficiency and Respiratory Syncytial Virus with Severe Lower Respiratory Tract Infection in Newborn Intensive Care Unit
The results suggest that severe lower respiratory tract infections is associated with lower vitamin D levels among newborns admitted in neonatal intensive care unit and vitamin D supplementation could help correct this deficiency and prevent postnatal severe lower ventilation tract infections. Expand
Adaptation to Mediterranea
Important genetics and pathogenesis features of diseases commonly encountered in the Mediterranean region with a short discussion of potential adaptations that they may carry are summarized. Expand
Physiological Status of HIV Infected Patients Pre ART
Although antiretroviral therapy has transformed the HIV infection status from non-curable to treatable and manageable, complications associated with the disease course and appearance of associated comorbid conditions still remains a concern for people living with HIV. Expand


Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity
The hormonal form of vitamin D up-regulates anti-microbial peptides, namely cathelicidin, to enhance clearance of bacteria at various barrier sites and in immune cells. Expand
Intervention in autoimmunity: the potential of vitamin D receptor agonists.
  • L. Adorini
  • Medicine, Biology
  • Cellular immunology
  • 2005
Mechanisms of action can explain some of the immunoregulatory properties of VDR agonists in the treatment of Th1-mediated autoimmune diseases, but may also represent a physiologic element in the VDR-mediated regulation of innate and adaptive immune responses. Expand
Vitamin D and immune function: Understanding common pathways
  • D. Bikle
  • Medicine, Biology
  • Current osteoporosis reports
  • 2009
1,25(OH)2D3 may be protective against various autoimmune diseases and may limit graft rejection by suppressing adaptive immunity while enhancing the first line of defense against invading microorganisms via upregulation of innate immunity. Expand
Vitamin D and the intracrinology of innate immunity
  • M. Hewison
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • 2010
It is now clear that sub-optimal vitamin D status is a common feature of many populations throughout the world, with the potential to compromise monocyte/macrophage metabolism of 25OHD and subsequent actions of 1,25(OH)(2)D. Expand
The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells
Microarray technology identified over 102 targets of 1,25(OH)2D3 in CD4+ T cells, two of which are regulators of NFkB and other genes of interest included the IL‐2Rβ gene and IgE binding factor. Expand
1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP31
The results suggest that 1,25(OH)2D3 and IL-2 have direct synergistic effects on activated T cells, acting as potent anti-inflammatory agents and physiologic inducers of adaptive regulatory T cells. Expand
Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
It is found that 1,25(OH)2D3 may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B Cell-mediated autoimmune disorders. Expand
Immunomodulatory effects of Vitamin D in multiple sclerosis.
Levels of 1,25(OH)(2)D(3) plays an important role in T cell homeostasis during the course of multiple sclerosis, thus making correction of its deficiency may be useful during treatment of the disease. Expand
Vitamin D: modulator of the immune system.
1,25(OH)(2)D(3) is described as an immunomodulator targeting various immune cells, including monocytes, macrophages, dendritic cells (DCs), as well as T-lymphocytes and B-LYmphocytes, hence modulating both innate and adaptive immune responses. Expand
Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts
  • E. Etten, C. Mathieu
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 2005
The availability of 1,25(OH)(2)D(3) analogs with immunomodulatory activity at non-hypercalcemic doses may allow exploitation of their immunommodulatory effects in a clinical setting of treatment of autoimmune diseases and prevention of allograft rejection. Expand