VITAMIN A DEFICIENCY INCREASES INFLAMMATORY RESPONSES

@article{Wiedermann1996VITAMINAD,
  title={VITAMIN A DEFICIENCY INCREASES INFLAMMATORY RESPONSES},
  author={Ursula Wiedermann and X.‐J. Chen and Lennart Enerb{\"a}ck and Lars {\AA}ke Hanson and Helena Kahu and Ulf I Dahlgren},
  journal={Scandinavian Journal of Immunology},
  year={1996},
  volume={44}
}
The authors studied the influence of vitamin A deficiency on immediate and delayed type hypersensitivity as well as granulocyte‐mediated inflammatory reactions in vitamin A depleted and control rats. The number of circulating leucocytes was 43% higher in the vitamin A deficient than in the control animals. The leucocytosis was a result of a general increase of white blood cells and was not due to an increase in one particular type. The ratio between CD4+ and CD8+ T cells was unchanged. The… 

Vitamin A as an anti-inflammatory agent

  • R. Reifen
  • Medicine, Biology
    Proceedings of the Nutrition Society
  • 2002
TLDR
The present review suggests that vitamin A deficiency induces inflammation and aggravates existing inflammatory states, and Supplementation with vitamin A in selected cases could ameliorate inflammation.

Vitamin A Deficiency in Mice Enhances the Colonic Level of Purine Enzyme Activity

TLDR
VAD causes upregulation of purine enzyme, which together with an increased number of inflammatory cells might exacerbate colonic injuries in VAD condition, and increased expression of adenosine deaminase in Vad mice colon is shown.

Vitamin A, infection, and immune function.

TLDR
Vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished, presumably account for the increased mortality seen in vitamin A-deficient infants, young children, and pregnant women in many areas of the world today.

Vitamin A deficiency exacerbates inflammation in a rat model of colitis through activation of nuclear factor-kappaB and collagen formation.

TLDR
The data suggest that vitamin A deficiency induces colonic inflammation, which is amplified by deficiency and ameliorated by supplementation of the vitamin.

PNS1200007 290..297

TLDR
Vitamin A deficiency increases a Th1 response in the presence of obesity and thus, increases the inflammatory process involved in chronic inflammation and fat deposition.

Repeated allergen challenge in rats increases vitamin A consumption.

TLDR
It is concluded that vitamin A utilization is increased during repeated allergen challenge and allergic bronchitis, most probably due to increased demand for epithelial repair.

Vitamin A status does not influence neopterin production during illness or health in South African children

TLDR
The results indicate that, contrary to what is observed in rodents under experimental conditions, poor vitamin A status is not associated with altered regulation of IFN-γ production in children.

Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type II pneumocytes.

TLDR
Evidence is provided that vitamin A deficiency produces profound morphologic alterations in liver and lung parenchyma and impairs pneumocyte function, as well as in the small arteries and arterioles, but not in the larger ones.

Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses

TLDR
The possible role of vitamin A deficiency in Common variable immunodeficiency is examined, which is a group of B‐cell deficiency syndromes with impaired antibody production and recurrent bacterial infections as the major manifestations.
...

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The increased IL-2 and IFN-gamma levels may reflect an up-regulation of Th1 cell function, while the decreased IgA, IgE and IL-6 levels indicate a suppression of Th2 cells.

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TLDR
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TLDR
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