VITAMIN A DEFICIENCY INCREASES INFLAMMATORY RESPONSES

@article{Wiedermann1996VITAMINAD,
  title={VITAMIN A DEFICIENCY INCREASES INFLAMMATORY RESPONSES},
  author={Ursula Wiedermann and Xiang Jian Chen and Lennart Enerb{\"a}ck and Lars {\AA}ke Hanson and Helena Kahu and Ulf I Dahlgren},
  journal={Scandinavian Journal of Immunology},
  year={1996},
  volume={44}
}
The authors studied the influence of vitamin A deficiency on immediate and delayed type hypersensitivity as well as granulocyte‐mediated inflammatory reactions in vitamin A depleted and control rats. The number of circulating leucocytes was 43% higher in the vitamin A deficient than in the control animals. The leucocytosis was a result of a general increase of white blood cells and was not due to an increase in one particular type. The ratio between CD4+ and CD8+ T cells was unchanged. The… Expand
Vitamin A as an anti-inflammatory agent
  • R. Reifen
  • Biology, Medicine
  • Proceedings of the Nutrition Society
  • 2002
TLDR
The present review suggests that vitamin A deficiency induces inflammation and aggravates existing inflammatory states, and Supplementation with vitamin A in selected cases could ameliorate inflammation. Expand
Vitamin A Deficiency in Mice Enhances the Colonic Level of Purine Enzyme Activity
TLDR
VAD causes upregulation of purine enzyme, which together with an increased number of inflammatory cells might exacerbate colonic injuries in VAD condition, and increased expression of adenosine deaminase in Vad mice colon is shown. Expand
Vitamin A, infection, and immune function.
TLDR
Vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished, presumably account for the increased mortality seen in vitamin A-deficient infants, young children, and pregnant women in many areas of the world today. Expand
Vitamin A deficiency exacerbates inflammation in a rat model of colitis through activation of nuclear factor-kappaB and collagen formation.
TLDR
The data suggest that vitamin A deficiency induces colonic inflammation, which is amplified by deficiency and ameliorated by supplementation of the vitamin. Expand
PNS1200007 290..297
Obesity has been associated with low-grade systemic inflammation and with micronutrient deficiencies. Obese individuals have been found to have lower vitamin A levels and lower vitamin A intakeExpand
Vitamin A deficiency leads to severe functional disturbance of the intestinal epithelium enzymes associated with diarrhoea and increased bacterial translocation in gnotobiotic rats.
TLDR
The observation, that the deficient vitamin A status led to a strong reduction of enterocyte enzymic activities, associated with diarrhoea and increased bacterial translocation, mainly in the gnotobiotic rats, suggests that the composition of the bacterial flora has a strong influence on triggering the severity of the functional disturbances of the intestinal epithelium, and adds to the clinical manifestations of vitamin A deficiency. Expand
Repeated allergen challenge in rats increases vitamin A consumption.
TLDR
It is concluded that vitamin A utilization is increased during repeated allergen challenge and allergic bronchitis, most probably due to increased demand for epithelial repair. Expand
Vitamin A status does not influence neopterin production during illness or health in South African children.
TLDR
The results indicate that, contrary to what is observed in rodents under experimental conditions, poor vitamin A status is not associated with altered regulation of IFN-gamma production in children. Expand
Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type II pneumocytes.
TLDR
Evidence is provided that vitamin A deficiency produces profound morphologic alterations in liver and lung parenchyma and impairs pneumocyte function, as well as in the small arteries and arterioles, but not in the larger ones. Expand
Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses
TLDR
The possible role of vitamin A deficiency in Common variable immunodeficiency is examined, which is a group of B‐cell deficiency syndromes with impaired antibody production and recurrent bacterial infections as the major manifestations. Expand
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The results suggest that the increased susceptibility to S. aureus infection observed in the vitamin-A-deficient rats is due to a concerted action of antigen-specific T-cell hyperactivity, impaired function of the phagocytes, and decreased complement activity. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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