VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCε-dependent manner.

Abstract

Vasoactive intestinal peptide (VIP) is a topical airway gland secretagogue regulating fluid secretions, primarily by stimulating cystic fibrosis transmembrane conductance regulator (CFTR)-dependent chloride secretion that contributes to the airways innate defense mechanism. We previously reported that prolonged VIP stimulation of pituitary adenylate cyclase… (More)
DOI: 10.1152/ajpcell.00296.2013

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@article{Alshafie2014VIPRC, title={VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCε-dependent manner.}, author={Walaa Alshafie and Fr{\'e}d{\'e}ric G Chappe and Mansong Li and Younes Anini and Val{\'e}rie M. Chappe}, journal={American journal of physiology. Cell physiology}, year={2014}, volume={307 1}, pages={C107-19} }