VIP receptors and control of short circuit current in the human intestinal clonal cell line Cl.19A

@article{RouyerFessard1989VIPRA,
  title={VIP receptors and control of short circuit current in the human intestinal clonal cell line Cl.19A},
  author={Christiane Rouyer-Fessard and Chantal Augeron and Etienne Grasset and J. J. Maoret and Christian L. Laboisse and Marc Laburthe},
  journal={Experientia},
  year={1989},
  volume={45},
  pages={1102-1105}
}
At the maximally effective concentration of 10 nM, VIP induced a marked (12.5-fold stimulation above basal), and sustained increase in short circuit current in the human intestinal epithelial cell line Cl.19A grown on permeable filters and placed in Ussing chambers. Half-maximal increase of Isc was observed for 0.1 nM VIP. This was well correlated with the VIP-stimulated adenylate cyclase activity (ED50:0.07 nM). Binding studies using125I-VIP indicated that Cl.19A cells express a peptide… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…