VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts.

@article{GutirrezCaas2006VIPDT,
  title={VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts.},
  author={Irene Guti{\'e}rrez-Ca{\~n}as and Yasmina Juarranz and Bego{\~n}a Santiago and Alicia Arranz and Carmen Mart{\'i}nez and Mar{\'i}a Galindo and M{\'o}nica Pay{\'a} and Rosa P Gomariz and Jos{\'e} Luis Pablos},
  journal={Rheumatology},
  year={2006},
  volume={45 5},
  pages={527-32}
}
OBJECTIVES Vasoactive intestinal peptide (VIP) has demonstrated therapeutic effects in arthritis by inhibiting both innate and acquired immune responses. We investigated the potential effects of VIP in the regulation of Toll-like receptor (TLR) expression and function in synovial fibroblasts from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). METHODS Cultured fibroblast-like synoviocytes (FLS) were obtained from patients with RA and OA. The effects of VIP on basal or TNF… CONTINUE READING
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