VIP and PHM and their role in nonadrenergic inhibitory responses in isolated human airways.

@article{Palmer1986VIPAP,
  title={VIP and PHM and their role in nonadrenergic inhibitory responses in isolated human airways.},
  author={James Dean Palmer and Francis M. Cuss and Peter J Barnes},
  journal={Journal of applied physiology},
  year={1986},
  volume={61 4},
  pages={1322-8}
}
There is increasing evidence in many species that vasoactive intestinal peptide (VIP) may be a neurotransmitter in nonadrenergic inhibitory nerves. We have studied the effect of electrical field stimulation (EFS), exogenous VIP, and isoproterenol (Iso) on human airways in vitro. We have also studied a related peptide, peptide histidine methionine (PHM), which coexists with VIP in human airway nerves, and in separate experiments studied fragments of the VIP amino acid sequence (VIP1-10 and VIP16… CONTINUE READING