VIP (Etoposide, Ifosfamide, Cisplatin) in Adult Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors

@article{ElWeshi2004VIPI,
  title={VIP (Etoposide, Ifosfamide, Cisplatin) in Adult Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors},
  author={Amr El Weshi and Muhammad Ali Memon and Madras A. Raja and Shouki Bazarbashi and Mohamed M. Rahal and M el Foudeh and Chandrashekhar Pai and Ayman A. Allam and Ibrahim M El Hassan and Adnan A. Ezzat},
  journal={American Journal of Clinical Oncology},
  year={2004},
  volume={27},
  pages={529-534}
}
Despite the fact that Ewing sarcoma family of tumors (ET) is chemosensitive, long-term survival is extremely rare for patients with primary refractory or recurrent disease. There is no standard salvage chemotherapy regimen available in this context. In this study the authors reviewed their experience with the combination of etoposide, ifosfamide, and cisplatin in adult patients with recurrent or refractory disease. From February 1997 through December 2001, they evaluated the efficacy of… 
VIP (etoposide, ifosfamide, and cisplatin) in patients with previously treated soft tissue sarcoma
TLDR
Outcomes of treatment with VIP (combination of etoposide, ifosfamide, and cisplatin) in patients with previously treated soft tissue sarcoma (STS) are retrospectively reviewed and it is suggested that VIP might be effective in patientsWith previously treated STS.
Single-Centre Experience of Systemic Treatment with Vincristine, Ifosfamide, and Doxorubicin Alternating with Etoposide, Ifosfamide, and Cisplatin in Adult Patients with Ewing Sarcoma
TLDR
This report retrospectively evaluated the response rates, outcome, and tolerance of adult patients treated with VIA/VIP between 1990 and 2014 and described the experience with the alternating use of triple combination therapies based on vincristine, ifosfamide, and doxorubicin (VIA) and an etoposide, ifo, and cisplatin combination (VIP).
Survival and prognostic factors in adult patients with recurrent or refractory ewing sarcoma family tumours: a 13-years retrospective study in Turkey.
TLDR
In primary refractory or relapsed ESFT, the presence of extrapulmonary metastases and treatment with salvage regimens other than ifosfamide and etoposide and/or carboplatin correlate with a poor prognosis.
Treatment of adult patients with Ewing’s sarcoma: compliance with chemotherapy protocols & toxicity
TLDR
A multidisciplinary approach including multi-agent chemotherapy for a prolonged period of time is appropriate in adult patients with ESFT, and dose intensity of chemotherapy should be determined according to the patient’s clinical status and comorbidities.
Etoposide and carbo‐or cisplatin combination therapy in refractory or relapsed Ewing sarcoma: A large retrospective study
TLDR
This work investigated the outcome of the combination treatment for patients with advanced Ewing sarcoma in progression after standard treatment and found no published data available yet.
Extraskeletal Ewing sarcomas in late adolescence and adults: a study of 37 patients.
TLDR
Multimodality therapy featuring wide surgical margins, aggressive chemotherapy and adjuvant local radiotherapy is necessary for this rare disease with high recurrence and frequent distant metastasis.
Prediction of response and prognostic factors for Ewing family of tumors in a low incidence population
TLDR
A non-pelvic primary tumor was a favorable predictor of responsiveness to chemotherapy, and Chemo-resistant patients might less benefit from second line chemotherapy.
Clinical and pathological features of primary neuroectodermal tumor/Ewing sarcoma of the kidney.
TLDR
The findings suggest that PNET/EWS is a rare aggressive tumor affecting principally young people, with a poor prognosis for patients with M1 disease; chemotherapy is an effective strategy in M1 Disease and probably also in M0 disease.
Extraosseous Ewing Sarcoma: Diagnosis, Prognosis and Optimal Management
TLDR
Pat characteristics and outcomes seem to be different in EES compared to patients with skeletal Ewing sarcoma, with implications for patient care and prognosis, and multimodality therapeutic strategies are recommended for all types of the Ewing tumour family.
Primary paraesophageal Ewing’s sarcoma: an uncommon case report and literature review
TLDR
An uncommon case of primary paraesophageal Ewing’s sarcoma in a 25-year-old male harboring the infrequent EWSR1/ERG fusion transcript with multiple splice variants coexisting in the same tumor is reported.
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