VICKZ proteins mediate cell migration via their RNA binding activity.

@article{Oberman2007VICKZPM,
  title={VICKZ proteins mediate cell migration via their RNA binding activity.},
  author={Froma Oberman and Kinneret Rand and Yael Maizels and Ariel M. Rubinstein and Joel K. Yisraeli},
  journal={RNA},
  year={2007},
  volume={13 9},
  pages={1558-69}
}
The highly conserved, RNA binding VICKZ proteins help regulate RNA localization, stability, and translation in many eukaryotes. These proteins are also required for cell migration in embryos and cultured cells. In adults, many tumors overexpress VICKZ homologs, and it has been hypothesized that the proteins can mediate cell motility and invasion. How these proteins facilitate cell movement and, in particular, whether their ability to bind RNA plays a role in their function remain unclear. Using… CONTINUE READING