VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma.

@article{Schraml2002VHLMA,
  title={VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma.},
  author={Peter Schraml and Kirsten Struckmann and Florian Hatz and S. J. Jean-Pierre Sonnet and Charlotte Kully and T. Christian Gasser and Guido Sauter and Michael J. Mihatsch and Holger Moch},
  journal={The Journal of pathology},
  year={2002},
  volume={196 2},
  pages={
          186-93
        }
}
Mutations of the von Hippel-Lindau (VHL) gene are considered critical for the initiation of clear cell renal cell carcinoma. The VHL protein is involved in regulation of the cell cycle and neo-vascularization. In this study, the association of VHL mutations with tumour cell proliferation, angiogenesis, and clinical outcome was analysed in 113 clear cell renal cell carcinomas. The degree of angiogenesis and tumour cell proliferation was immunohistochemically determined by counting microvessels… CONTINUE READING

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