VH3 family antibodies bind domain D of staphylococcal protein A.

@article{Roben1995VH3FA,
  title={VH3 family antibodies bind domain D of staphylococcal protein A.},
  author={P W Roben and A. Michael Salem and Gregg J Silverman},
  journal={Journal of immunology},
  year={1995},
  volume={154 12},
  pages={6437-45}
}
Staphylococcal protein A (SpA) is a 45-kDa bacterial membrane protein that can interact with either Fc gamma, a constant region portion of IgG, or with the Fab portion that also mediates conventional Ag binding. In recent reports, SpA has been shown to specifically interact with Fab derived from the VH3 family and is little affected by VH CDR3, JH, or light chain usage. To identify a site on SpA responsible for VH3 Fab binding, we cloned and expressed in Escherichia coli the 61 amino acid… CONTINUE READING

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