VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes.

The pathogenesis of chronic tendinopathy is unclear. We have previously measured high intratendinous levels of glutamate in patients with tendinosis, suggesting potential roles of glutamate in the modulation of pain, vascular function, and degenerative changes including apoptosis of tenocytes. However, the origin of free glutamate found in tendon tissue is… CONTINUE READING