VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo.

@article{Zhai1999VEGIAN,
  title={VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo.},
  author={Yali Zhai and Jian Ni and Guoan Jiang and Junxuan Lu and Ligang Xing and Clint Lincoln and Kenneth C. Carter and Fouad Janat and Darby Kozak and Shuyun Xu and Lourdes Rojas and Bharat Bhushan Aggarwal and Steve M. Ruben and L Y Li and Reiner Gentz and Geliang L Yu},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1999},
  volume={13 1},
  pages={181-9}
}
A novel member of the tumor necrosis factor (TNF) family has been identified from the human umbilical vein endothelial cell cDNA library, named vascular endothelial growth inhibitor (VEGI). The VEGI gene was mapped to human chromosome 9q32. The cDNA for VEGI encodes a protein of 174 amino acid residues with the characteristics of a type II transmembrane protein. Its amino acid sequence is 20-30% identical to other members of the TNF family. Unlike other members of the TNF family, VEGI is… CONTINUE READING