VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

  title={VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread},
  author={Xiujuan Li and Narendra Padhan and Elisabet O. Sj{\"o}str{\"o}m and Francis P. Roche and Chiara Testini and Naoki Honkura and Miguel S{\'a}inz-Jaspeado and Emma J. Gordon and Katie Bentley and Andrew Philippides and Vladimir Tolmachev and Elisabetta Dejana and Radu V Stan and Dietmar Vestweber and Kurt Ballmer-Hofer and Christer Betsholtz and Kristian Pietras and Leif Jansson and Lena Claesson-Welsh},
  booktitle={Nature communications},
The specific role of VEGFA-induced permeability and vascular leakage in physiology and pathology has remained unclear. Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. Abolished Y949 signalling in the mouse mutant Vegfr2(Y949F/Y949F) leads to VEGFA-resistant endothelial adherens junctions and a block in molecular extravasation. Vessels in Vegfr2(Y949F/Y949F) mice remain… CONTINUE READING
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