VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications.

@article{Robciuc2016VEGFBVEGFR1InducedEO,
  title={VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications.},
  author={Marius Robert Robciuc and Riikka Kivel{\"a} and Ian M. Williams and Jan Freark de Boer and Theo H. van Dijk and Harri Elamaa and Feven Tigistu-Sahle and Dmitry A Molotkov and Veli-Matti Lepp{\"a}nen and Reijo K{\"a}kel{\"a} and Lauri Eklund and David H. Wasserman and Albert K. Groen and Kari Alitalo},
  journal={Cell metabolism},
  year={2016},
  volume={23 4},
  pages={712-24}
}
Impaired angiogenesis has been implicated in adipose tissue dysfunction and the development of obesity and associated metabolic disorders. Here, we report the unexpected finding that vascular endothelial growth factor B (VEGFB) gene transduction into mice inhibits obesity-associated inflammation and improves metabolic health without changes in body weight… CONTINUE READING