VEGFA splicing: divergent isoforms regulate spermatogonial stem cell maintenance

  title={VEGFA splicing: divergent isoforms regulate spermatogonial stem cell maintenance},
  author={Kevin M. Sargent and Debra T. Clopton and Ningxia Lu and William E. Pohlmeier and Andrea S. Cupp},
  journal={Cell and Tissue Research},
Despite being well-known for regulating angiogenesis in both normal and tumorigenic environments, vascular endothelial growth factor A (VEGFA) has been recently implicated in male fertility, namely in the maintenance of spermatogonial stem cells (SSC). The VEGFA gene can be spliced into multiple distinct isoforms that are either angiogenic or antiangiogenic in nature. Although studies have demonstrated the alternative splicing of VEGFA, including the divergent roles of the two isoform family… CONTINUE READING
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