VEGFA +936C>T polymorphism and cancer risk: a meta-analysis.

Abstract

Vascular endothelial growth factor A (VEGF-A), a major driver of physiological and pathological angiogenesis, plays important roles in the etiology and metastasis of cancers. The +936C>T polymorphism in the 3'-untranslated region of the VEGFA gene has been implicated in cancer risk and is related to VEGF-A protein production; however, published data have been conflicting. To derive a more precise estimation of the relationship, a meta-analysis was performed of 13,293 cancer cases and 12,308 control subjects from 29 published case-control studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between +936C>T polymorphism and cancer risk. The meta-analysis indicated that individuals with the +936 T had increased risk of oral cancer (OR = 1.39, 95% CI = 1.03-1.88), although no association was found in the contrast of T versus C (OR = 1.00, 95% CI = 0.91-1.10) in the pooled analyses. This meta-analysis supports the idea that VEGFA + 936 T is associated with increased risk of oral cancer. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VEGFA + 936C>T polymorphism and cancer risk.

DOI: 10.1016/j.cancergencyto.2009.11.007

Statistics

020040020102011201220132014201520162017
Citations per Year

427 Citations

Semantic Scholar estimates that this publication has 427 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Xu2010VEGFAP, title={VEGFA +936C>T polymorphism and cancer risk: a meta-analysis.}, author={Bin Xu and Jiu-ming Li and Na Tong and Jun Tao and Peng-chao Li and Ning-hong Song and Wei Zhang and Hong-fei Wu and Ning-han Feng and Li-xin Hua}, journal={Cancer genetics and cytogenetics}, year={2010}, volume={198 1}, pages={7-14} }