VEGF188 promotes corneal reinnervation after injury

  title={VEGF188 promotes corneal reinnervation after injury},
  author={James T. Brash and L. Denti and C. Ruhrberg and F. Bucher},
  journal={JCI Insight},
  • James T. Brash, L. Denti, +1 author F. Bucher
  • Published 2019
  • Medicine
  • JCI Insight
  • Vascular endothelial growth factor A (VEGF) induces angiogenesis and vascular hyperpermeability in ocular tissues and is therefore a key therapeutic target for eye conditions in which these processes are dysregulated. In contrast, the therapeutic potential of VEGF’s neurotrophic roles in the eye has remained unexploited. In particular, it is not known whether modulating levels of any of the 3 major alternatively spliced VEGF isoforms might provide a therapeutic approach to promote neural health… CONTINUE READING
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