VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A

  title={VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A},
  author={Ra{\'u}l Catena and Leyre Larz{\'a}bal and Marta Larr{\'a}yoz and Eva Molina and Jos{\'e} Ram{\'o}n Fern{\'a}ndez Hermida and Jackeline Agorreta and R. Perez Montes and Rub{\'e}n P{\'i}o and Luis M. Montuenga and Alfonso Benito Calvo},
  booktitle={Molecular Cancer},
Different isoforms of VEGF-A (mainly VEGF121, VEGF165 and VEGF189) have been shown to display particular angiogenic properties in the generation of a functional tumor vasculature. Recently, a novel class of VEGF-A isoforms, designated as VEGFxxxb, generated through alternative splicing, have been described. Previous studies have suggested that these isoforms may inhibit angiogenesis. In the present work we have produced recombinant VEGF121/165b proteins in the yeast Pichia pastoris and… CONTINUE READING
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