VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans

Abstract

Tumor angiogenesis depends on the vascular endothelial growth factor (VEGF), which exists in multiple splicing isoforms, including the most abundant VEGF165 and VEGF121. We have previously shown that the differential capacity of these two VEGF isoforms to bind Neuropilin-1 accounts for their diverse ability to recruit Nrp1-expressing monocytes (NEMs… (More)
DOI: 10.1038/cgt.2016.12

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