VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells.

@article{Beierle2002VEGFUB,
  title={VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells.},
  author={Elizabeth Ann Beierle and Louise F Strande and Mike K S Chen},
  journal={Journal of pediatric surgery},
  year={2002},
  volume={37 3},
  pages={467-71}
}
BACKGROUND/PURPOSE Both the expression of Bcl-2 and the amount of vascular endothelial growth factor (VEGF) are increased in neuroblastoma cells cocultured with hepatocytes. The authors hypothesize that VEGF upregulates Bcl-2 expression by the neuroblastoma cells and protects them from apoptotic stimuli. METHODS To determine whether VEGF will induce Bcl-2 expression in neuroblastoma cells, the cells are plated with standard media (control) or media supplemented with VEGF. After 24 hours, Bcl… CONTINUE READING

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