VEGF signaling has distinct spatiotemporal roles during heart valve development.

@article{Stankunas2010VEGFSH,
  title={VEGF signaling has distinct spatiotemporal roles during heart valve development.},
  author={Kryn Stankunas and Gene K Ma and Frank J Kuhnert and Calvin Kuo and Ching-Pin Chang},
  journal={Developmental biology},
  year={2010},
  volume={347 2},
  pages={325-36}
}
Heart valve malformations are one of the most common types of birth defects, illustrating the complex nature of valve development. Vascular endothelial growth factor (VEGF) signaling is one pathway implicated in valve formation, however its specific spatial and temporal roles remain poorly defined. To decipher these contributions, we use two inducible dominant negative approaches in mice to disrupt VEGF signaling at different stages of embryogenesis. At an early step in valve development, VEGF… CONTINUE READING

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