VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus.

@article{Waltenberger2009VEGFRA,
  title={VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus.},
  author={Johannes Waltenberger},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 6},
  pages={1167-70}
}
The action of VEGF (vascular endothelial growth factor) is essential to maintain proper endothelial and vascular function. VEGF stimulates virtually all aspects of endothelial function, namely proliferation, migration, permeability and nitric oxide production and release. In addition, the action of VEGF makes the endothelium anti-apoptotic. In turn, the inhibition of VEGF action is associated with endothelial dysfunction. Likewise, endothelial dysfunction can be found in the presence of several… CONTINUE READING