VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.

@article{Lanahan2010VEGFR2,
  title={VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.},
  author={A. Lanahan and K. Hermans and Filip Claes and Joanna S. Kerley-Hamilton and Z. Zhuang and F. Giordano and P. Carmeliet and M. Simons},
  journal={Developmental cell},
  year={2010},
  volume={18 5},
  pages={
          713-24
        }
}
VEGF is the key growth factor regulating arterial morphogenesis. However, molecular events involved in this process have not been elucidated. Synectin null mice demonstrate impaired VEGF signaling and a marked reduction in arterial morphogenesis. Here, we show that this occurs due to delayed trafficking of VEGFR2-containing endosomes that exposes internalized VEGFR2 to selective dephosphorylation by PTP1b on Y(1175) site. Synectin involvement in VEGFR2 intracellular trafficking requires myosin… Expand
The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis
TLDR
It is demonstrated that the N RP1 cytoplasmic domain promotes VEGFR2 trafficking in a PDZ-dependent manner to regulate arteriogenic ERK signaling and establish a role for NRP1 in VEGF-A signaling during vascular morphogenesis. Expand
The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling.
TLDR
It is demonstrated that unconventional myosin 1c (Myo1c; class I family member) regulates the localization of VEGFR2 at the plasma membrane (PM) and plays a role in angiogenic signaling. Expand
Coordination of VEGF receptor trafficking and signaling by coreceptors.
TLDR
The body of evidence is compelling that VEGF receptor trafficking is coordinated with other proteins such as Neuropilin-1, ephrin-B2, VE-cadherin and protein phosphatases, and the latest findings concerning endocytosis and intracellular trafficking of VEGFRs are reviewed. Expand
Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis
TLDR
It is shown that zebrafish sec14l3, one of the family members, specifically participates in artery and vein formation via regulating angioblasts and subsequent venous progenitors’ migration during vasculogenesis via the regulation of VEGFR2 activation. Expand
VEGFR2 trafficking: Speed doesn’t kill
TLDR
This work has shown that deletion of the NRP1 cytoplasmic domain in arterial endothelial cells gives rise to delayed trafficking of VEGFR2, which causes prolonged exposure to PTP1b and a decrease in Tyr1175 phosphorylation, which leads to reduced ERK1/2 activation and impaired arteriogenesis. Expand
The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis
TLDR
It is reported that the early endosomal GTPase Rab5C and its activator RIN2 prevent lysosomal routing and degradation of VEGF-bound, internalized VEGFR2 in human endothelial cells. Expand
Spatial regulation of VEGF receptor endocytosis in angiogenesis
TLDR
This work uncovers how vessel growth is dynamically controlled by local VEGF receptor endocytosis and the activity of cell polarity proteins. Expand
FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling
TLDR
FGD5 regulates VEGFR2 retention in recycling endosomes and coupling to PI3 (phosphoinositide-3) kinase/mTORC2-dependent cytoskeletal remodeling and regulates VESF retention in recyclable endosome recycling. Expand
KIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2
TLDR
KIF13B is an essential molecular motor required for the trafficking of VEGFR2 from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis. Expand
Regulation of VEGF signaling by membrane traffic.
TLDR
The recent detection of only mild vascular defects in a knockin mouse model that expresses Nrp1 lacking a cytoplasmic domain, questions the co-receptor's role in VEGF signaling and membrane traffic. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 49 REFERENCES
Vascular Endothelial Growth Factor and Semaphorin Induce Neuropilin-1 Endocytosis via Separate Pathways
TLDR
The results show that the endocytic pathway of Nrp1 is determined by its ligand and that the trafficking of NnP1 is essential for its signaling. Expand
The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling
TLDR
It is concluded that matrix-controlled TCPTP phosphatase activity can inhibit VEGFR2 signalling, and the growth, migration and differentiation of human endothelial cells. Expand
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
TLDR
It is concluded that PI3K-ERK1/2 crosstalk plays a key role in the regulation of arterial growth and that the augmentation of ERK signaling via suppression of thePI3K signaling pathway can effectively stimulate arteriogenesis. Expand
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
TLDR
VEC limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments, and silencing the junction-associated density-enhanced phosphatase-1/CD148 phosph atase restores VEGfr-2 internalization and signaling. Expand
Selective regulation of arterial branching morphogenesis by synectin.
TLDR
It is concluded that synectin is involved in selective regulation of arterial, but not venous, growth and branching morphogenesis and that Rac1 plays an important role in this process. Expand
Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells
TLDR
It is proposed that Nrp1 modulation of α5β1 integrin function can play a causal role in the generation of angiogenesis defects observed in N rp1 null mice. Expand
Down-regulation of epidermal growth factor receptor signalling within multivesicular bodies.
TLDR
How the phosphorylation state of components of the MVB sorting machinery, as well as the EGFR, may play a critical role in regulating EGFR sorting and signalling is reviewed. Expand
New Role for the Protein Tyrosine Phosphatase DEP-1 in Akt Activation and Endothelial Cell Survival
TLDR
The results reveal that despite its negative role on global VEGFR2 phosphorylation, DEP-1 is a positive regulator of VEGF-mediated Src and Akt activation and endothelial cell survival. Expand
Type I Collagen Limits VEGFR-2 Signaling by a SHP2 Protein-Tyrosine Phosphatase–Dependent Mechanism 1
TLDR
It is demonstrated that collagen I in provisional extracellular matrix surrounding nascent capillaries triggers a signaling pathway that negatively regulates angiogenesis. Expand
Transcriptional profiling reveals a critical role for tyrosine phosphatase VE‐PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis
TLDR
One of the identified genes, VE‐PTP, regulates VEGFR2 activity thereby modulating the VEGF‐response during angiogenesis, and may serve critical functions in formation of the vascular tube. Expand
...
1
2
3
4
5
...