VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells.

  title={VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells.},
  author={Naoki Oka and Akio Soeda and Akihito Inagaki and Masafumi Onodera and Hidekazu Maruyama and Akira Hara and Takahiro Kunisada and Hideki Mori and Toru Iwama},
  journal={Biochemical and biophysical research communications},
  volume={360 3},
There is increasing evidence for the presence of cancer stem cells (CSCs) in malignant brain tumors, and these CSCs may play a pivotal role in tumor initiation, growth, and recurrence. Vascular endothelial growth factor (VEGF) promotes the proliferation of vascular endothelial cells (VECs) and the neurogenesis of neural stem cells. Using CSCs derived from human glioblastomas and a retrovirus expressing VEGF, we examined the effects of VEGF on the properties of CSCs in vitro and in vivo… CONTINUE READING


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