VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration.

  title={VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration.},
  author={Yaoming Wang and Kunlin Jin and Xiao Ou Mao and Lin Xie and Surita Banwait and Hugo H. Marti and David Greenberg},
  journal={Journal of neuroscience research},
  volume={85 4},
New neurons are generated continuously in the subventricular zone and dentate gyrus of the adult brain. Neuropathologic processes, including cerebral ischemia, can enhance neurogenesis, as can growth factors and other physiologic stimuli. Vascular endothelial growth factor (VEGF) is an angiogenic and neuroprotective growth factor that can promote neurogenesis, but it is unknown whether VEGF can enhance migration of newborn neurons toward sites of ischemic injury, where they might be able to… CONTINUE READING


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