VEGF modulation of retinal pigment epithelium resistance.

  title={VEGF modulation of retinal pigment epithelium resistance.},
  author={Zsolt Ablonczy and Craig E. Crosson},
  journal={Experimental eye research},
  volume={85 6},
Fluid accumulation into the subretinal space and the development of macular edema is a common condition in age-related macular degeneration, diabetic retinopathy, and following ocular surgery, or injury. Vascular endothelial growth factor (VEGF) and other cytokines have been implicated in the disruption of retinal pigment epithelium (RPE) barrier function and a reduction in the regulated removal of subretinal fluid; however, the cellular and molecular events linking these agents to the… CONTINUE READING