VEGF modulates early heart valve formation.

  title={VEGF modulates early heart valve formation.},
  author={Yuval Dor and Scott E. Klewer and John Alan McDonald and E. Keshet and Todd D. Camenisch},
  journal={The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology},
  volume={271 1},
Although hypoxic and/or nutritional insults during gestation are believed to contribute to congenital heart defects, the mechanisms responsible for these anomalies are not understood. Given the role vascular endothelial growth factor (VEGF) plays in response to hypoxia, it is a likely candidate for mediating deleterious effects of embryonic hypoxia. The ectopic or overproduction of endogenous factors such as VEGF may contribute to specific heart defects. Here we compared hypoxia-induced… CONTINUE READING

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