VEGF links hippocampal activity with neurogenesis, learning and memory

  title={VEGF links hippocampal activity with neurogenesis, learning and memory},
  author={Lei Cao and Xiangyang Jiao and David S Zuzga and Yuhong Liu and Dahna M Fong and Deborah Young and Matthew John During},
  journal={Nature Genetics},
An enriched environment is associated with hippocampal plasticity, including improved cognitive performance and increased neurogenesis. Here, we show that hippocampal expression of vascular endothelial growth factor (VEGF) is increased by both an enriched environment and performance in a spatial maze. Hippocampal gene transfer of VEGF in adult rats resulted in ∼2 times more neurogenesis associated with improved cognition. In contrast, overexpression of placental growth factor, which signals… CONTINUE READING


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