VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

@article{Lambrechts2003VEGFIA,
  title={VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death},
  author={Diether Lambrechts and Erik Storkebaum and Masafumi Morimoto and J. Del-favero and Frederik Desmet and Stefan Lars Marklund and Sabine Wyns and Vincent Thijs and J{\"o}rgen Andersson and Ingrid van Marion and Ammar Al-Chalabi and St{\'e}phanie Bornes and Rhiannon Musson and Val{\'e}rie Hansen and Lars Beckman and Rolf Adolfsson and Hardev Singh Pall and H. Prats and S{\'e}verine Vermeire and P. R. Rutgeerts and Shigehiro Katayama and Takuya Awata and Nigel Leigh and Lo{\"i}c Lang-Lazdunski and Mieke Dewerchin and Christopher T. Shaw and Lieve Moons and Robert F M H Vlietinck and Karen E. Morrison and Wim Robberecht and Christine Van Broeckhoven and D{\'e}sir{\'e} Collen and Peter Munch Andersen and Peter Carmeliet},
  journal={Nature Genetics},
  year={2003},
  volume={34},
  pages={383-394}
}
Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons. We recently reported that reduced expression of Vegfa causes ALS-like motoneuron degeneration in Vegfaδ/δ mice. In a meta-analysis of over 900 individuals from Sweden and over 1,000 individuals from Belgium and England, we now report that subjects homozygous with respect to the haplotypes −2,578A/−1,154A/−634G or −2,578A/−1,154G/−634G in the VEGF promoter/leader sequence had a 1.8 times greater risk of ALS… CONTINUE READING
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