VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide.

@article{Breslin2003VEGFIE,
  title={VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide.},
  author={J. W. Breslin and P. Pappas and J. Cerveira and R. Hobson and W. Dur{\'a}n},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 1},
  pages={
          H92-H100
        }
}
  • J. W. Breslin, P. Pappas, +2 authors W. Durán
  • Published 2003
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • We tested the hypothesis that VEGF regulates endothelial hyperpermeability to macromolecules by activating the ERK-1/2 MAPK pathway. We also tested whether PKC and nitric oxide (NO) mediate VEGF-induced increases in permeability via the ERK-1/2 pathway. FITC-Dextran 70 flux across human umbilical vein endothelial cell monolayers served as an index of permeability, whereas Western blots assessed the phosphorylation of ERK-1/2. VEGF-induced hyperpermeability was inhibited by antisense DNA… CONTINUE READING
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