VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide.

@article{Breslin2003VEGFIE,
  title={VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide.},
  author={Jerome W Breslin and Peter J. Pappas and Joaquim J Cerveira and Robert W. Hobson and Walter N. Dur{\'a}n},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 1},
  pages={H92-H100}
}
We tested the hypothesis that VEGF regulates endothelial hyperpermeability to macromolecules by activating the ERK-1/2 MAPK pathway. We also tested whether PKC and nitric oxide (NO) mediate VEGF-induced increases in permeability via the ERK-1/2 pathway. FITC-Dextran 70 flux across human umbilical vein endothelial cell monolayers served as an index of permeability, whereas Western blots assessed the phosphorylation of ERK-1/2. VEGF-induced hyperpermeability was inhibited by antisense DNA… CONTINUE READING

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