VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease.

@article{Kalka2000VEGFGT,
  title={VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease.},
  author={Christoph Kalka and Hassan Farbod Mofidi Tehrani and Bernd Laudenberg and Peter R. Vale and Jeffrey M. Isner and Takayuki Asahara and James F Symes},
  journal={The Annals of thoracic surgery},
  year={2000},
  volume={70 3},
  pages={829-34}
}
BACKGROUND Direct transfection of ischemic myocardium with naked plasmid DNA encoding for vascular endothelial growth factor-165 (VEGF165) has been shown to mobilize endothelial progenitor cells (EPCs). This study examined the kinetics of circulating EPCs isolated from peripheral blood mononuclear cells after gene transfer, and their role in neovascularization of ischemic myocardium. METHODS The mononuclear cell population was isolated from peripheral venous blood samples of patients with… CONTINUE READING
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