VEGF directly suppresses activation of T cells from ovarian cancer patients and healthy individuals via VEGF receptor Type 2.

@article{Ziogas2012VEGFDS,
  title={VEGF directly suppresses activation of T cells from ovarian cancer patients and healthy individuals via VEGF receptor Type 2.},
  author={Apostolos C Ziogas and Nikos G. Gavalas and Marinos Tsiatas and Ourania E. Tsitsilonis and Ekaterini Politi and Evangelos Terpos and Alexandros J Rodolakis and George E. Vlahos and Nikolaos Thomakos and Dimitrios A Haidopoulos and Aristidis Antsaklis and Meletios Athanasios Dimopoulos and Aristotelis Bamias},
  journal={International journal of cancer},
  year={2012},
  volume={130 4},
  pages={857-64}
}
The role of vascular endothelial growth factor (VEGF) in tumor angiogenesis is well characterized; nevertheless, it is also a key element in promoting tumor evasion of the immune system by downregulating dendritic cell maturation and thus T cell activation. We sought to investigate the possible direct effect of VEGF on T cell activation and through which type of VEGF receptor (VEGFR) it exerts this effect. Circulating T cells from healthy donors and ovarian cancer patients were expanded in… CONTINUE READING
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