VEGF-directed blood vessel patterning: from cells to organism.

Abstract

VEGF-A signaling is required for almost every aspect of vascular development, and it is a major regulator of vessel morphogenesis and patterning. VEGF-A perturbations are associated with severe vascular defects and lethality, and the pathway is coopted in pathological scenarios, including tumor angiogenesis. This review focuses on the roles of VEGF-A… (More)
DOI: 10.1101/cshperspect.a006452

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