VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis

@inproceedings{Takyar2013VEGFCL,
  title={VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis},
  author={S A Taghavi Takyar and Hema H. Vasavada and Jian-ge Zhang and Farida Ahangari and Naiqian Niu and Qing Liu and Chun Geun Lee and Lauren Cohn and Jack A Elias},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Asthma, the prototypic Th2-mediated inflammatory disorder of the lung, is an emergent disease worldwide. Vascular endothelial growth factor (VEGF) is a critical regulator of pulmonary Th2 inflammation, but the underlying mechanism and the roles of microRNAs (miRNAs) in this process have not been defined. Here we show that lung-specific overexpression of VEGF decreases miR-1 expression in the lung, most prominently in the endothelium, and a similar down-regulation occurs in lung endothelium in… CONTINUE READING
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