VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms

@article{Schoeffner2005VEGFCT,
  title={VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms},
  author={Daniel J Schoeffner and Shannon L Matheny and Takemi Akahane and Valentina M. Factor and Adam Berry and Glenn Merlino and Unnur P. Thorgeirsson},
  journal={Laboratory Investigation},
  year={2005},
  volume={85},
  pages={608-623}
}
Vascular endothelial growth factor (VEGF) has been identified as a vascular permeability factor, angiogenic cytokine, and a survival factor. To address its role in mammary carcinogenesis, we used transgenic mice with human VEGF165 targeted to mammary epithelial cells under the control of the mouse mammary tumor virus (MMTV) promoter. Metastatic mammary carcinomas were induced by mating the MMTV-VEGF mice with MMTV-polyoma virus middle T-antigen (MT) mice to generate VEGF/MT mice. Tumor latency… CONTINUE READING

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