VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes

@article{Taylor2015VEGFCP,
  title={VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes},
  author={Stephanie L. Taylor and Dustin Trudeau and Brendan Arnold and Joshua Wang and Craig E Brown},
  journal={Neurobiology of Disease},
  year={2015},
  volume={78},
  pages={1-11}
}
Clinical and experimental studies have shown a clear link between diabetes, vascular dysfunction and cognitive impairment. However, the molecular underpinnings of this association remain unclear. Since vascular endothelial growth factor (VEGF) signaling is important for maintaining vascular integrity and function, we hypothesized that vascular and cognitive impairment in the diabetic brain could be related to a deficiency in VEGF signaling. Here we show that chronic hyperglycemia (~8weeks) in a… CONTINUE READING

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